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However, the cellular stress of the upstream events, i.e., reactive metabolite formation, GSH depletion, and protein adducts formation, is still present and this stress may trigger apoptosis in a limited number of cells (Figure 1)

Given that cellular senescence is now recognized as one of the primary pillars of biological aging, this third mechanism elevates MOTS-c from a metabolic peptide to a potential geroscience intervention

We propose that long-term extra sugar intake multiple times a day can gradually sweep the -cells away, and suggest that simultaneously taking glutathione, an antioxidant, in each meal could prevent blood glucose/ROS-induced detrimental effects on -cell

It has been estimated that one puff of cigarette smoke contains approximately 10 15 free radicals of various origins (Yang et al