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Yan X, Xia Y, Li B et al (2024) The SOX4/EZH2/SLC7A11 signaling axis mediates ferroptosis in calcium oxalate crystal deposition-induced kidney injury
The study included six experimental groups with six to eight rats per group, including: nave or uninjured, vehicle control, frostbite-injured rats treated with DALDA at three doses ranging from 1, 3, and 10 mg/kg, subcutaneously, and a standard treatment group receiving 100 mg/kg ibuprofen, intraperitoneally [2]
Supporting natural detoxification is therefore less about dramatic interventions and more about removing friction from a system thats already working hard
Lysates were complemented with 0.6 U/mL glutathione reductase (Sigma, G3664), 0.2 mM nicotinamide adenine dinucleotide phosphate hydrogen (NADPH, Sigma, N7505), 3 mM reduced glutathione (GSH, Sigma, G4251) and 200 M of the substrate cumene hydroperoxide (CHP, Sigma, 247502)
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