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72 GLP-1R knockout mice exhibit significantly reduced expression of key genes involved in epithelial protection and repair, including trefoil factor (Tff)1, Tff2, TGF-1, TGF-3, epidermal growth factor receptor (Egfr), keratinocyte growth factor (Fgf7), and hepatocyte growth factor (Hgf), implicating GLP-1R signaling in mucosal healing pathways

Drug-drug interactions, particularly with opioids and CYP3A4 inhibitors, are examined due to their synergistic sedative potential

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Upon mutation, residue conformation was chosen according to highest probability from the rotamer library (probability is taken from the library that was not affect the structural environment but changed in Phi and Psi angle when Dunbrack library was used)