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The drug was used in a double-blind, randomised, placebo-controlled trial including 526 adult participants with type 2 diabetes across China, India, Japan, Mexico, and the United States

3.3 Tirzepatide effects: cardiovascular, renal, hepatic, and other metabolic effects of tirzepatide Due to concerns that type 2 diabetes medications increased cardiovascular risk, the FDA issued guidance for pharmaceutical companies to perform cardiovascular outcomes trials for new diabetes medications

One study reported the presence of GLP-1R on the membrane of human liver cells, which undergoes endocytosis following GLP-1RA stimulation and acts by regulating downstream molecules of insulin signaling

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