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The largest arm of ibutamoren containing an indoline-3,4-piperidine ring structure forms hydrophobic and cation- interactions with the side chains of GHSR residues F286 6.58 and R102 2.63 , respectively

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(PubMed) Miller ER, 3 rd , Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar E

The AtFer1 isoform is functionally involved in events leading to the onset of age-dependent senescence in Arabidopsis and its iron-detoxification function during senescence is required when ROS accumulates (Murgia et al., 2007)