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The pathophysiology centres on aberrant activation of the immune system, with elevated levels of pro-inflammatory cytokines such as tumour necrosis factor-alpha (TNF-) , interleukin-17 (IL-17) , and interleukin-23 (IL-23)

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Who Benefits More: Practical Guidance and Provider Considerations Semaglutide may be preferred for patients with mild to moderate GI sensitivity, those seeking a simpler single-pathway mechanism, or individuals who tolerate incremental dose escalation well