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This is one reason semaglutide tends to produce the most dramatic early results in people with higher starting weights

In addition, the label is updated to include data from SELECT showing a risk reduction in cardiovascular death by 15% and a risk reduction of death from any cause by 19%, both compared to placebo (Cardiovascular death superiority not confirmed (hazard ratio: 0.85 (0.71;1.01) and death by any cause not statistically significant based on the prespecified testing hierarchy (hazard ratio: 0.81 (0.71

Lower maintenance doses help prevent rebound while reducing drug exposure

This side effect is usually temporary and gets better as your body gets used to the medicine