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Medline, Embase and Cochrane, to search for studies during pregnancy and/or lactation with maternal exposure to a GLP-1 agonist or an SGLT2 inhibitor ( Supplement 46 )

The CME Institute has resolved any conflicts of interest that were identified

Diabetes Care 48(9):16221627 Kahn SE, Deanfield JE, Jeppesen OK, Emerson SS, Boesgaard TW, Colhoun HM, Kushner RF, Lingvay I, Burguera B, Gajos G, Horn DB, Hramiak IM, Jastreboff AM, Kokkinos A, Maeng M, Matos ALSA, Tinahones FJ, Lincoff AM, Ryan DH, SELECT Trial Investigators (2024) Effect of semaglutide on regression and progression of glycemia in people with overweight or obesity but without diabetes in the SELECT trial

These trade-offs will likely inform how clinicians and the FDA approach the final approved dose range