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It also acts on vagal afferent neurons that signal the brain on gut nutrient status

The decision to continue, modify, or discontinue GLP-1 receptor agonist therapy should be individualised, considering the balance between therapeutic benefit and adverse effects

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With the exception of the subgroup with a GFR of less than 30 mL/min/1.73m 2 , the 3-year cumulative incidence of all-cause death was significantly lower in patients who received semaglutide than those who received dulaglutide