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IV therapy delivers 100% absorption at doses 10-50 times higher, creating therapeutic blood concentrations impossible to achieve orally
2-cyano-3,12 dioxooleana-1,9 diene-28-imidazolide (CDDO-Im) and 2-cyano-3,12 dioxooleana-1,9, diene-28-methyl ester (CDDO-Me) induce caspase-independent cell death in pancreatic cancer in vitro and prevent the growth of pancreatic cancer xenografts in vivo
Biopsies underwent immunofluorescence staining for BSEP, a canalicular membrane marker (CD-13), and nuclei (DAPI) followed by 40X confocal imaging (3 random areas were imaged per sample)
12,21,22 The opening of the mitochondrial permeability transition pore under pathological conditions, such as oxidative stress, calcium overload, or energy depletion, leads to disruption of the mitochondrial membrane potential and the release of proapoptotic factors, ultimately culminating in cell death
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