Because it is still in the clinical trial phase globally, its long-term safety profile and benefit-risk balance are still being evaluated
Summary: Retatrutide, an investigational GLP-1/GIP/glucagon triple agonist, most commonly causes gastrointestinal side effects, and no direct human fertility data currently exist, though indirect reproductive benefits via weight loss are plausible
The estimated treatment difference was 8.03%, and higher than the weight change difference in the non-bariatric patients treated with liraglutide, which had been reported as 4.8% in a recent systematic review and meta-analysis of randomized controlled trials [50]
Unlike single GLP-1 receptor research compounds, Retatrutide is associated with GLP-1, GIP, and glucagon receptor pathway research , which is why it is frequently discussed in relation to triple-agonist research models